, Michel Dallaporta and Bernard Thorens Homeostasis Brain Glucose Sensing , Counterregulation , and Energy
نویسندگان
چکیده
Physiol. Soc.. ESSN: 1548-9221. Visit our website at http://www.the-aps.org/. Sci./Am. American Physiological Society, 9650 Rockville Pike, Bethesda MD 20814-3991. © 2007 Int. Union Physiol. the physiological developments. It is published bimonthly in February, April, June, August, October, and December by (formerly published as News in Physiological Science) publishes brief review articles on major Physiology by gest on S etem er 7, 2016 http://physioline.physiology.org/ D ow nladed fom
منابع مشابه
Brain glucose sensing, counterregulation, and energy homeostasis.
Neuronal circuits in the central nervous system play a critical role in orchestrating the control of glucose and energy homeostasis. Glucose, beside being a nutrient, is also a signal detected by several glucose-sensing units that are located at different anatomical sites and converge to the hypothalamus to cooperate with leptin and insulin in controlling the melanocortin pathway.
متن کاملNell Marty , Michel Dallaporta and Bernard Thorens Homeostasis Brain Glucose
Physiol. Soc.. ESSN: 1548-9221. Visit our website at http://www.the-aps.org/. Sci./Am. American Physiological Society, 9650 Rockville Pike, Bethesda MD 20814-3991. © 2007 Int. Union Physiol. the physiological developments. It is published bimonthly in February, April, June, August, October, and December by (formerly published as News in Physiological Science) publishes brief review articles on ...
متن کاملSex-Specific Control of Fat Mass and Counterregulation by Hypothalamic Glucokinase.
Glucokinase (Gck) is a critical regulator of glucose-induced insulin secretion by pancreatic β-cells. It has been suggested to also play an important role in glucose signaling in neurons of the ventromedial hypothalamic nucleus (VMN), a brain nucleus involved in the control of glucose homeostasis and feeding. To test the role of Gck in VMN glucose sensing and physiological regulation, we studie...
متن کاملEvidence from glut2-null mice that glucose is a critical physiological regulator of feeding.
A role for glucose in the control of feeding has been proposed, but its precise physiological importance is unknown. Here, we evaluated feeding behavior in glut2-null mice, which express a transgenic glucose transporter in their beta-cells to rescue insulin secretion (ripglut1;glut2-/- mice). We showed that in the absence of GLUT2, daily food intake was increased and feeding initiation and term...
متن کاملHypoglycemia-activated GLUT2 neurons of the nucleus tractus solitarius stimulate vagal activity and glucagon secretion.
Glucose-sensing neurons in the brainstem participate in the regulation of energy homeostasis but have been poorly characterized because of the lack of specific markers to identify them. Here we show that GLUT2-expressing neurons of the nucleus of the tractus solitarius form a distinct population of hypoglycemia-activated neurons. Their response to low glucose is mediated by reduced intracellula...
متن کامل